CHAI vs Clinical Judgment: A New Frontier in NMIBC Personalization
CHAI vs Clinical Judgment: A New Frontier in NMIBC Personalization

Drs. Vignesh T. Packiam and Nitin Yerram explore the latest advances in NMIBC, including combination immunotherapy with BCG, emerging data in papillary disease, and the development of AI-driven biomarkers like CHAI to guide personalized treatment decisions.

In this segment, they break down the development of the CHAI biomarker, an AI-powered pathology tool trained on over 1,000 patient samples from 10 institutions, designed to predict response to BCG in high-grade NMIBC.

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Latest News

Next-Line Thinking: Optimizing Treatment Beyond ARPIs in mCRPC
Next-Line Thinking: Optimizing Treatment Beyond ARPIs in mCRPC
Scott Sellinger, MDProstate Cancer | July 14, 2025
The panel discusses the evolving treatment landscape for mCRPC, focusing on the role of RLTs and PARP inhibitors.
Upfront Matters: Navigating Treatment Intensification in mCSPC
Upfront Matters: Navigating Treatment Intensification in mCSPC
Scott Sellinger, MDProstate Cancer | July 14, 2025
The panel discusses treatment intensification strategies for mCSPC, emphasizing the shift toward doublet and triplet therapy.
Delaying ADT, Preserving Quality: Smarter Choices in Metastatic Prostate Cancer
Delaying ADT, Preserving Quality: Smarter Choices in Metastatic Prostate Cancer
Scott Sellinger, MDProstate Cancer | July 14, 2025
The panel discusses the growing role of advanced molecular imaging and genomic testing in prostate cancer care.
The Modern Landscape of Advanced Prostate Cancer: Diagnosis, Risk, and Imaging
The Modern Landscape of Advanced Prostate Cancer: Diagnosis, Risk, and Imaging
Scott Sellinger, MDProstate Cancer | July 14, 2025
The panel begins with the landscape of advanced PC care, emphasizing accurate categorization of disease stage and burden.
Bevacizumab and Erlotinib Combination May Help HLRCC-Linked Papillary RCC
Bevacizumab and Erlotinib Combination May Help HLRCC-Linked Papillary RCC
Jessica GanganccRCC | July 11, 2025
Phase 2 trial examines efficacy and response of bevacizumab/erlotinib for treatment of patients with rare subtypes of RCC.
PSA Anxiety and Patient Fears: Navigating De-escalation Conversations
PSA Anxiety and Patient Fears: Navigating De-escalation Conversations
Shahid S. Ahmed, MDmCSPC | July 10, 2025
Drs. Ahmed and Ciuro discuss the real-world quality-of-life improvements patients may experience after de-escalating therapy.
When Less Is More: Safe De-escalation in Oligometastatic Prostate Cancer
When Less Is More: Safe De-escalation in Oligometastatic Prostate Cancer
Shahid S. Ahmed, MDmCSPC | July 10, 2025
Drs. Ahmed and Ciuro explore the rationale and complexity behind treatment de-escalation in de novo oligometastatic HSPC.
Can PSMA PET Imaging Predict Lu-PSMA Outcomes?
Can PSMA PET Imaging Predict Lu-PSMA Outcomes?
Koichiro Kimura, MD, PhDRLT | July 8, 2025
Dr. Kimura shares insights on PSMA PET/CT metrics and their potential role in guiding treatment decisions for mCRPC.
Stereotactic Ablative Body Radiotherapy More Effective, Less Expensive for Patients With Inoperable RCC
Stereotactic Ablative Body Radiotherapy More Effective, Less Expensive for Patients With Inoperable RCC
Emily MenendezLocalized Renal Cell Carcinoma | July 8, 2025
Despite an initial decrease in HRQOL after SABR, the procedure is more effective and less expensive than RFA & ...
NEOAVAX Trial: Neoadjuvant Avelumab and Axitinib for Localized High-Risk RCC
NEOAVAX Trial: Neoadjuvant Avelumab and Axitinib for Localized High-Risk RCC
Axel Bex, MD, PhDLocalized Renal Cell Carcinoma | July 1, 2025
Professor Bex discusses the phase II NEOAVAX trial that evaluated avelumab/axitinib as neoadjuvant therapy in localized RCC.
Intravesical Gemcitabine/Docetaxel as First-Line Therapy for Patients With NMIBC
Intravesical Gemcitabine/Docetaxel as First-Line Therapy for Patients With NMIBC
Jessica GangaNon-Muscle Invasive Urothelial Carcinoma | July 1, 2025
Researchers find promise in Gem/Doce as an alternative therapy for patients with NMIBC recurrence after BCG induction.
Targeting CD70 With ALLO-316 in Advanced Clear Cell RCC: Updated Phase 1 Results From TRAVERSE
Targeting CD70 With ALLO-316 in Advanced Clear Cell RCC: Updated Phase 1 Results From TRAVERSE
Samer Srour, MBAdvanced Renal Cell Carcinoma | June 30, 2025
Samer Srour, MB, talks about the updated ALLO-316 and its use in targeting CD70 in patients with advanced ccRCC.
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Editorial Advisory Board
Brian Rini, MD, FASCO
Brian Rini, MD, FASCOEditor | Chief of Clinical Trials at Vanderbilt-Ingram Cancer Center
Thomas Powles, MBBS, MRCP, MD
Thomas Powles, MBBS, MRCP, MDEditor | Director, Barts Cancer Centre at St. Bartholomew's Hospital
Katy Beckermann, MD, PhD
Katy Beckermann, MD, PhDEditor | Medical Director of GU Clinical Research at Tennessee Oncology
Christopher Wallis, MD, PhD, FRCSC
Christopher Wallis, MD, PhD, FRCSCAssistant Professor of Urology | University of Toronto
Akhil Abraham Saji, MD
Akhil Abraham Saji, MDEditor | Urologist at Swedish Health Services
David Ambinder, MD
David Ambinder, MDEditor | Urology Resident at New York Medical College/Westchester Medical Center

The Uromigos Live and Unplugged 2024

The Uromigos Live & Unplugged 2024
The Uromigos Live & Unplugged 2024

The Uromigos Live & Unplugged 2024 took place September 27-29 in Nashville, Tennessee.

This meeting was the third annual in-person event hosted by Thomas Powles, MD, and Brian Rini, MD, FASCO, in partnership with Mashup Media, featuring expert panels and audience discussion around the latest data in genitourinary oncology and vision for the future.

Expert Interviews

Teaching TURBT Over 5G: Integrating XR Headsets Into Urologic Practice
Teaching TURBT Over 5G: Integrating XR Headsets Into Urologic Practice
Evan Kovac, MDProstate Cancer | May 19, 2025
Dr. Evan Kovac speaks about his pioneering work with extended reality display technology in urologic surgery and education.
Bladder Cancer Without Cystectomy: Dr. Alexandre Zlotta on the Maturation of Trimodality Therapy
Bladder Cancer Without Cystectomy: Dr. Alexandre Zlotta on the Maturation of Trimodality Therapy
Alexandre Zlotta, MDMuscle Invasive Urothelial Carcinoma | May 15, 2025
Dr. Zlotta discusses the current state and future of bladder-sparing therapy in MIBC, including how to best select patients.
From VEGF to HIF-2 Targeting Drugs: Dr. James Brugarolas’ Journey to Transforming Kidney Cancer Treatment
From VEGF to HIF-2 Targeting Drugs: Dr. James Brugarolas’ Journey to Transforming Kidney Cancer Treatment
James “Jim” Brugarolas, MD, PhDRenal Cell Carcinoma | April 22, 2025
Dr. Brugarolas reflects on his lab's role in developing HIF-2 inhibitors and his ongoing work to improve patient outcomes.
Bladder-Sparing Innovations in MIBC: Dr. Elizabeth Plimack on the RETAIN Approach and Its Future
Bladder-Sparing Innovations in MIBC: Dr. Elizabeth Plimack on the RETAIN Approach and Its Future
Elizabeth Plimack, MD, MS, FASCOMuscle Invasive Urothelial Carcinoma | June 25, 2025
Dr. Plimack details RETAIN, from early findings with neoadjuvant ddMVAC to the evolution of RETAIN-1 and RETAIN-2.
Precision in Prostate Cancer: Dr. Amir Lebastchi on Tailoring Focal Therapy for Optimal Outcomes
Precision in Prostate Cancer: Dr. Amir Lebastchi on Tailoring Focal Therapy for Optimal Outcomes
Akhil Abraham Saji, MDLocalized | June 25, 2025
Drs. Saji and Lebastchi explore focal therapy, covering its historical evolution, techniques, and energy modalities.
Ahmed E. Ghazi – Revolutionizing and Scaling Surgical Training Through Simulation Models
Ahmed E. Ghazi – Revolutionizing and Scaling Surgical Training Through Simulation Models
David Ambinder, MDLocalized | June 25, 2025
Dr. Ghazi is recognized as a pioneer in patient-specific surgical simulation, using state-of-the-art techniques in surgery.

Knowledge Hubs

Curated clinical content based on conditions, therapies, and technologies

Prostate Cancer
Prostate Cancer
CRPC
CRPC
Localized
Localized
Prostate Cancer Diagnostics
Prostate Cancer Diagnostics
RLT
RLT
mHSPC/mCSPC
mHSPC/mCSPC
Renal Cell Carcinoma
Renal Cell Carcinoma
Localized Renal Cell Carcinoma
Localized Renal Cell Carcinoma
Advanced Renal Cell Carcinoma
Advanced Renal Cell Carcinoma
nccRCC
nccRCC
Renal Cell Carcinoma Diagnostics
Renal Cell Carcinoma Diagnostics
Testicular, Penile, and Rare Malignancies
Testicular, Penile, and Rare Malignancies
Urothelial Carcinoma
Urothelial Carcinoma
Advanced Urothelial Carcinoma
Advanced Urothelial Carcinoma
Muscle Invasive Urothelial Carcinoma
Muscle Invasive Urothelial Carcinoma
Non-Muscle Invasive Urothelial Carcinoma
Non-Muscle Invasive Urothelial Carcinoma
Upper Tract Urothelial Carcinoma
Upper Tract Urothelial Carcinoma
Urothelial Carcinoma Diagnostics
Urothelial Carcinoma Diagnostics
Prostate Cancer
Prostate Cancer
CRPC
CRPC
Localized
Localized
Prostate Cancer Diagnostics
Prostate Cancer Diagnostics

The Uromigos

Podcasts hosted by Professors Thomas Powles, MD, and Brian Rini, MD

Episode 430: Structured Exercise Improves DFS/OS After Adjuvant Therapy in Colorectal Cancer - Does This Apply to GU Cancers?
Episode 430: Structured Exercise Improves DFS/OS After Adjuvant Therapy in Colorectal Cancer - Does This Apply to GU Cancers?
Recent data that showed higher OS after exercise in patients with colorectal cancer are reviewed in the context of GU cancer.
# Posted on July 8, 2025
Episode 428: ASCO 2025 Recap
Episode 428: ASCO 2025 Recap
Dr. Silke Gillessen joins the show to discuss highlights from the ASCO 2025 Annual Meeting with Brian and Tom.
# Posted on June 16, 2025
Episode 427: Emerging Data in Non-Muscle Invasive Bladder Cancer
Episode 427: Emerging Data in Non-Muscle Invasive Bladder Cancer
Dr. Joshua Meeks joins the podcast to give a stellar overview of emerging data in the NMIBC space.
# Posted on June 16, 2025
# Uromigos-Bladder Cancer

Conference Coverage

Live meeting highlights

Can PSMA PET Imaging Predict Lu-PSMA Outcomes?
Koichiro Kimura, MD, PhDRLT | July 8, 2025
Dr. Kimura shares insights on PSMA PET/CT metrics and their potential role in guiding treatment decisions for mCRPC.
View More
NEOAVAX Trial: Neoadjuvant Avelumab and Axitinib for Localized High-Risk RCC
Axel Bex, MD, PhDLocalized Renal Cell Carcinoma | July 1, 2025
Professor Bex discusses the phase II NEOAVAX trial that evaluated avelumab/axitinib as neoadjuvant therapy in localized RCC.
View More
Targeting CD70 With ALLO-316 in Advanced Clear Cell RCC: Updated Phase 1 Results From TRAVERSE
Samer Srour, MBAdvanced Renal Cell Carcinoma | June 30, 2025
Samer Srour, MB, talks about the updated ALLO-316 and its use in targeting CD70 in patients with advanced ccRCC.
View More
Radiopharmaceutical Trials in Prostate Cancer: Evolving Treatments and Combination Therapies
Robert Flavell, MD, PhDRLT | June 27, 2025
Dr. Flavell discusses how landmark studies have shaped current trial designs, and growing interest in combination therapies.
View More

Video Insights

Clinical discussions with experts in the field

Network Websites

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GI Oncology Now is the leading medical news resource for practicing oncologists and health care providers treating gastrointestinal malignancies, offering the latest study data and research breakthroughs related to colorectal, gastric, liver, pancreatic, and esophageal cancers.

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A medical news property for practicing oncologists treating lung malignancies, Lung Cancers Today features breaking news, commentary, expert interviews, and data analysis to inform providers on the latest research and most effective clinical practices in the lung cancers space.

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