Dr. Galsky shares the first OS data update on the CheckMate 274 trial, which he gave at the 2024 EAU Congress. Dr. Joshi contextualizes the THOR study within the treatment landscape for FGFR2/3-altered advanced urothelial carcinoma. Dr. Iagaru discusses the safety findings and clinical implications of his research. Dr. Ulaner highlights 2 new clinical trials for prostate cancer staging and treatment at Hoag: MIRROR and 177Lu-PNT2002. Drs. Atkins and Beckermann weigh the potential of targeting Tregs in RCC treatment, particularly in relation to PD-1 therapy. Drs. Atkins and Beckermann consider biomarkers for patient selection for LAG-3 inhibition and increasing cure rates in RCC. Drs. Atkins and Beckermann discuss LAG-3 as a novel checkpoint inhibitor combined with anti-PD-1 for kidney cancer.cC Drs. Grasso and Verhovsky discuss the potential of endoscopic treatment with surveillance for patients with bladder cancer. Dr. Myers and colleagues challenge the current paradigm of discouraging additional BCG therapy for "unresponsive" NMIBC. Dr. Canfield shares real-world active surveillance among men with localized PC tested with the genomic prostate score assay. Dr. Spratt reviews the safety and efficacy of relugolix plus RT in patients with localized or advanced prostate cancer. Dr. Ferguson sheds light on a national analysis evaluating the role of lymph node dissection in patients with high-risk UTUC. Dr. Ferguson highlights the latest TAR-210 and TAR-200 data in select patients with non-muscle invasive bladder cancer. The panel continues discussing their phase 3 PSMA PET/CT trial expectations for the final data readout in 2025. The panel from UCLA highlights their study on the impact of PSMA PET/CT on prostate cancer salvage radiotherapy management. Dr. Djaladat discusses how the presence of specific biomarkers, such as CK|V oncosomes and D|CK|V cells, correlate with RFS. Dr. Birtle describes the utility of carboplatin versus cisplatin in this regimen and discusses metastasis-free survival. Dr. Birtle highlights the trial's findings regarding the long-term overall survival benefit of adjuvant chemotherapy. Dr. Sonpavde provides an overview of the potential of nivo/gem-cis for patients with mUC who are ineligible for EV/pembro. The POUT trial investigated adjuvant chemo for improving disease-specific survival in patients with UTUC.