Dr. Emmett discusses the Co-PSMA trial, comparing ⁶⁴Cu-SAR-bisPSMA and ⁶⁸Ga-PSMA-11 for detecting prostate cancer ... Dr. Tran discusses the benefits of the Decipher score as well as how stratified patients respond differently. Germline genetic testing is underused for patients with prostate cancer, despite many being eligible for the procedure. Enzalutamide with [177Lu]Lu-PSMA-617 improved OS and HRQOL, along with PSA PFS. Dr. Tan discusses the TALAPRO-2 study, PARP inhibitor synergy, HRR testing, and evolving treatment strategies in mCRPC. Dr. Ciuro discusses key factors to consider when choosing between doublet and triplet therapy for mHSPC. The panel highlights key ASCO GU 2025 data, including TALAPRO-2, PSMA PET, the PORTOS score, and emerging therapies like EZH2 The panel discusses data from PEACE-3 and maintaining ARSI therapy with emerging combination treatments. The experts discuss treatment selection in mHSPC and share insights from STOPCAP and ARANOTE on ARSI use in older patients. The panel covers metastasis-directed therapy and trials including SWOG 1802 in oligometastatic prostate cancer. The panelists examine biomarker adoption challenges and the impact of PSMA PET on staging and treatment decisions. Experts discuss advances in biomarker testing, treatment intensification, and the impact of TALAPRO-2 in prostate cancer care The panel highlights the limitations of conventional imaging in detecting disease progression at undetectable PSA levels. The panel zooms in on the use of radium, enzalutamide, and other therapeutic agents, touching on patient preference trials. The panel focuses on decision-making between AR antagonists and abiraterone, weighing factors such as reimbursement. The panel goes in-depth on the use of testing and SBRT as metastasis-directed therapy in newly diagnosed prostate cancer. The panel explores the the role of imaging, genomics, and patient factors in the management of mHSPC. The combination demonstrated a manageable safety profile with evidence of EZH2 pharmacodynamic inhibition and OR. Drs. Karine Tawagi and Samantha Armstrong expand on the prostate cancer discussions of note, including TALAPRO-2. Dr. Sonpavde showcases a phase I/Ib clincial trial on the safety of a neoadjuvant darolutamide and relugolix combination.