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RLT
Radioligand therapy prostate-specific membrane antigen
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Positive Phase I Data of 177Lu rhPSMA-10.1 Supports Phase II Trial for mCRPC
Emily Menendez
RLT
|
October 9, 2024
Early phase I data on 177Lu rhPSMA-10.1 has demonstrated an encouraging safety profile for the novel radioligand therapy.
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Radioligands: Live Session From The Uromigos Live & Unplugged 2024
Brian Rini, MD, FASCO
RLT
|
October 3, 2024
The Radioligands panel at Uromigos Live & Unplugged 2024 explored the role of RLT in prostate cancer treatment.
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ESMO Congress 2024 GU Round-Up: Prostate Cancer
Christopher Wallis, MD, PhD, FRCSC
CRPC
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October 1, 2024
Drs. Tawagi and Wallis review the PEACE-III, STAMPEDE, UpFrontPSMA, and SPLASH studies trials at the ESMO Congress 2024.
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SPLASH: Comparative Outcomes of PSMA Radioligand Therapy Versus ARPI Switch in mCRPC
Karine Tawagi, MD
CRPC
|
October 3, 2024
SPLASH continues to show benefit for PSMA RLT in mCRPC and adds to this consideration in the pre-chemotherapy setting.
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Quantitative Analysis of 68Ga-PSMA-11 PET, Clinical Outcomes in Patients With mCRPC
Katy Marshall
CRPC
|
October 3, 2024
177Lu-PSMA-617 is a PSMA-targeted radioligand therapy in patients with mCRPC.
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De-escalated AcPSMA With and Without LuPSMA Offers Better Tolerability for Advanced Prostate Cancer
Emily Menendez
RLT
|
August 8, 2024
Multiple cycles of AcPSMA can cause side effects including salivary gland toxicity and xerostomia.
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Efficacy and Toxicity of 177Lu-PSMA-617 for mCRPC in a Real-World Setting
Vishnu Murthy
CRPC
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July 8, 2024
Vishnu Murthy discusses the real-world efficacy and toxicity of 177Lu-PSMA-617 for mCRPC.
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SNMMI 2024: Dosimetry of 177Lu-PSMA RLTs, FLEX-MRT, and More
Jérémie Calais, MD, PhD
RLT
|
June 20, 2024
Dr. Calais provides his list of the clinical trials of interest on imaging, RLT, and prostate cancer from the SNMMI meeting.
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Nuclear Medicine Highlights From the SNMMI 2024 Annual Meeting
Jérémie Calais, MD, PhD
RLT
|
June 20, 2024
Dr. Calais shares his thoughts on the sessions or abstracts that are of the most importance for practicing GU oncologists.
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PSMAfore Results: [177Lu]Lu-PSMA-617 in Taxane-Naive Patients With mCRPC
Oliver Sartor, MD
RLT
|
June 18, 2024
Dr. Sartor discusses the PSMAfore study, which examined [177Lu]Lu-PSMA-617 radioligand therapy in taxane-naive mCRPC.
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Rationale, Dose Escalation for 67Cu-SAR-bisPSMA in Patients With mCRPC
Geoffrey Johnson, MD, PhD
RLT
|
June 17, 2024
Dr. Johnson provides an overview of the SECuRE study, a phase 1/2a theranostic trial for treatment of PSMA-expressing mCRPC.
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177Lu-PSMA-617 Boosts Antitumor Effects in Real-World Setting for mCRPC
Emily Menendez
Prostate Cancer
|
June 13, 2024
177Lu-PSMA-617 in heavily pretreated patients with late-stage mCRPC provided beneficial antitumor effects.
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Intensified RLT Boosts Treatment Efficacy in Patients With mCRPC
Emily Menendez
CRPC
|
June 13, 2024
Intensified RLT with escalation of the first 3 cycles to 10-11 GBq for high-volume mCRPC may increase treatment efficacy.
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PSMAfore: Informing Future Trials of 177Lu-PSMA-617 Versus Chemotherapy for mCRPC
Karine Tawagi, MD
Advancements in Oncology
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June 12, 2024
Dr. Tawagi opines on whether the high rates of crossover in the PSMAfore control arm limit the applicability of the results.
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PSMA Tandem Treatment Offers Benefit for Patients With mCRPC
Zachary Bessette
RLT
|
June 11, 2024
A phase 3 trial offers the first randomized evidence of the benefit of PSMA tandem therapy in patients with mCRPC.
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Radioligand Therapy With [177Lu]Lu-PSMA I&T Shows Promising Safety, Efficacy in Elderly Patients With Prostate Cancer
Brandon Twyford
RLT
|
June 10, 2024
Study shows [177Lu]Lu-PSMA is safe and effective for elderly patients with mCRPC, improving PSA response and overall survival
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Prostate Cancer Management in Focus: Dr. Karine Tawagi’s Thoughts on 177Lu-PSMA-617
GU Oncology Now Editors
Advancements in Oncology
|
June 13, 2024
Dr. Karine Tawagi focused this part of her discussion on 177Lu-PSMA-617 and the PSMAfore trial updates.
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First-In-Human Study Evaluating Safety of JNJ-6420 for mCRPC
Michael Morris, MD
RLT
|
June 4, 2024
Dr. Morris discusses a phase 1 study of JNJ-6420 for patients with mCRPC who received at least prior ARPI.
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Enzalutamide Plus LuPSMA Improves PFS in mCRPC
Emily Menendez
CRPC
|
May 7, 2024
Previous research has shown that the effects of androgen and PSMA receptors can complement each other if used concurrently.
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Complete Response Observed in First Patient Treated With Multiple Doses of 67Cu-SAR-bisPSMA
Zachary Bessette
RLT
|
April 30, 2024
A CR was observed in the first patient with mCRPC to receive 2 cycles of 67Cu-SAR-bisPSMA at a dosage of 8GBq.
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