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CRPC
Metastatic castration-resistant prostate cancer
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Quantitative Analysis of 68Ga-PSMA-11 PET, Clinical Outcomes in Patients With mCRPC
Katy Marshall
CRPC
|
September 9, 2024
177Lu-PSMA-617 is a PSMA-targeted radioligand therapy in patients with mCRPC.
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Enzalutamide vs Abiraterone Acetate for mCRPC
Emily Menendez
CRPC
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August 30, 2024
Enzalutamide was associated with improvements in OS, PCS, TTS, and TTR compared with abiraterone acetate.
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Pembrolizumab Plus Enzalutamide for Patients With mCRPC
Katy Marshall
CRPC
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August 22, 2024
The study presented the results of cohorts 4 and 5 from the phase 2 KEYNOTE-199 study.
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DDIs, Drug-Comorbidity Interactions in ARPIs for mCRPC
Emily Menendez
CRPC
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August 2, 2024
The impact of potential comorbidities and concomitant medication interactions in ARPIs are not well understood.
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Androgen Signaling Combinations for mCRPC: Analyzing Ipilimumab Plus AAPA
Emily Menendez
CRPC
|
July 10, 2024
Abiraterone acetate, prednisone, and apalutamide is a common combination treatment for mCRPC.
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Efficacy and Toxicity of 177Lu-PSMA-617 for mCRPC in a Real-World Setting
Vishnu Murthy
CRPC
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July 8, 2024
Vishnu Murthy discusses the real-world efficacy and toxicity of 177Lu-PSMA-617 for mCRPC.
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Are Androgen Receptor Signaling Inhibitors Related to Cardiovascular Events in Advanced Prostate Cancer?
Katy Marshall
CRPC
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June 21, 2024
The study’s primary end points were the incidence of all-grade or grade 3 and higher cardiovascular events.
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SNMMI 2024: Dosimetry of 177Lu-PSMA RLTs, FLEX-MRT, and More
Jérémie Calais, MD, PhD
RLT
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June 20, 2024
Dr. Calais provides his list of the clinical trials of interest on imaging, RLT, and prostate cancer from the SNMMI meeting.
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PSMAfore Results: [177Lu]Lu-PSMA-617 in Taxane-Naive Patients With mCRPC
Oliver Sartor, MD
RLT
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June 18, 2024
Dr. Sartor discusses the PSMAfore study, which examined [177Lu]Lu-PSMA-617 radioligand therapy in taxane-naive mCRPC.
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Rationale, Dose Escalation for 67Cu-SAR-bisPSMA in Patients With mCRPC
Geoffrey Johnson, MD, PhD
RLT
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June 17, 2024
Dr. Johnson provides an overview of the SECuRE study, a phase 1/2a theranostic trial for treatment of PSMA-expressing mCRPC.
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Enhancing Genetic Testing Rates in Metastatic Prostate Cancer: Trends, Challenges, and Opportunities
Pedro Barata, MD
CRPC
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June 13, 2024
Dr. Pedro Barata discusses his research letter examining patterns of HRR mutation genetic testing in men with mCRPC.
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177Lu-PSMA-617 Boosts Antitumor Effects in Real-World Setting for mCRPC
Emily Menendez
Prostate Cancer
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June 13, 2024
177Lu-PSMA-617 in heavily pretreated patients with late-stage mCRPC provided beneficial antitumor effects.
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Intensified RLT Boosts Treatment Efficacy in Patients With mCRPC
Emily Menendez
CRPC
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June 13, 2024
Intensified RLT with escalation of the first 3 cycles to 10-11 GBq for high-volume mCRPC may increase treatment efficacy.
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PSMAfore: Informing Future Trials of 177Lu-PSMA-617 Versus Chemotherapy for mCRPC
Karine Tawagi, MD
Advancements in Oncology
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June 12, 2024
Dr. Tawagi opines on whether the high rates of crossover in the PSMAfore control arm limit the applicability of the results.
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ARAMIS Follow-Up: PSA Levels, Radiological Progression in nmCRPC
Alicia Morgans, MD, MPH
CRPC
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June 12, 2024
Drs. Morgans, Wallis dissect the association between PSA level of < 0.2 ng/mL and risk of radiological progression in ...
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PSMA Tandem Treatment Offers Benefit for Patients With mCRPC
Zachary Bessette
RLT
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June 11, 2024
A phase 3 trial offers the first randomized evidence of the benefit of PSMA tandem therapy in patients with mCRPC.
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Promising Phase 3 Trial Results for [177Lu]Lu-PSMA-617 in Taxane-Naive Patients With mCRPC
Brandon Twyford
CRPC
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June 10, 2024
The PSMAfore trial shows [177Lu]Lu-PSMA-617 significantly improves rPFS, ORR, and PSA50 in taxane-naive patients with mCRPC.
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Identifying Blood-Based Markers for Optimized Bipolar Androgen Therapy in mCRPC
Samuel Denmeade, MD
CRPC
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June 6, 2024
Dr. Denmeade highlights his research on blood-based markers of differential efficacy of BAT and enzalutamide in TRANSFORMER.
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Prostate Cancer Management in Focus: Dr. Karine Tawagi’s Thoughts on 177Lu-PSMA-617
GU Oncology Now Editors
Advancements in Oncology
|
June 13, 2024
Dr. Karine Tawagi focused this part of her discussion on 177Lu-PSMA-617 and the PSMAfore trial updates.
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Impact of Concomitant Therapies on Survival Outcomes in Non-Metastatic CRPC
Soumyajit Roy, MD
CRPC
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June 6, 2024
Drs. Soumyajit Roy and Christopher Wallis break down the latest secondary analysis of the SPARTAN trial.
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