Dr. Lotan discusses risk stratification and outlines the next steps for integrating Cxbladder Triage into clinical practice. Sasanlimab is being further studied in combination with other antibody drug conjugate treatments in advanced solid tumors. The indication for SG as a treatment for patients with pretreated aUC will be officially withdrawn by Gilead. Dr. Geynisman reviews the RETAIN 1 trial evaluating whether certain patients with MIBC can safely avoid invasive procedures. Dr. Tyson shares insights on the potential role of cretostimogene in treating BCG-unresponsive NMIBC, based on BOND-003 data. Dr. Lotan describes the design and key findings of the STRATA trial using Cxbladder Triage for patients with microhematuria. Patients who achieved a complete response after six doses of UGN-101 were followed up for 12 months after initial CR. Dr. Tyson reviews the findings from Cohort P of the BOND-003 trial on cretostimogene grenadenorepvec for NMIBC. Dr. Neal Shore discusses how the investigational treatment TARA-002 can aid patients during the ongoing BCG shortage. Dr. Neal Shore reviews the history of nadofaragene firadenovec in high-risk disease, and the anticipated outcomes of ABLE-32. Drs. Nizam and Packiam review the findings from a study on AI-powered biomarkers to aid NMIBC diagnosis and treatment. The FDA has approved nivo for subcutaneous injection for all solid tumors for which nivo is indicated as a monotherapy. Dr. Daneshmand discusses the impressive complete response rate and durability of TAR-200 monotherapy for NMIBC. In the PENELOPE study, TAR-200 showed greater tissue penetration of gemcitabine compared to standard intravesical therapy. The panelists share their insights on risk assessment, and customized treatment strategies for high-risk NMIBC. The panelists discuss the evolving landscape of bladder cancer treatments, focusing on balancing bladder-sparing therapies. The panelists debate the potential of combining intravesical immunotherapy with immune checkpoint inhibitors. The panelists share their perspectives on SunRISe-1 and the evolving role of TAR-200 in treating BCG-unresponsive UC. The second segment of this roundtable focuses on the evolving landscape of treatments for BCG-unresponsive bladder cancer. Part one of this roundtable highlights current practices, emerging therapies, and the future landscape of NMIBC care.