Dr. Sonpavde provides an update on the latest analysis from the phase 3 global study of EV in combination with pembro. Dr. Sonpavde provides an overview of a phase I/II trial in progress on V940 (mRNA-4157) for resected high-risk MIUC. Drs. Roupret and Houede dissect their research on the safety and efficacy of durvalumab with NAC for operable high-risk UTUC. Preliminary results of the study showed promising efficacy and safety with neoadjuvant treatment with DV plus toripalimab. EV with erdafitinib is a feasible combination with the ability to provide promising antitumor activity in mUC. Dr. Kitamura shares the differences observed between the JAVEMACS and JAVELIN Bladder 100 patient cohorts. Dr. Hassanzadeh elaborates on the benefits of MDT for patients with progressive or de novo disease. Drs. Grivas, Khaki, and Raychaudhuri discuss a phase II trial evaluating pembrolizumab plus aMVAC for non-UC MIBC. Dr. Nizam touched on her study of real-world safety of first-line therapies for locally advanced or metastatic UC in the US. Dr. Jain spoke to the rationale for combining erdafitinib with EV in mUC patients with FGFR3/2 genetic alterations. Dr. Kim discusses systemic therapy and surgical consolidation in node-positive upper tract urothelial carcinoma treatment. The ABLE-22 trial evaluates nadofaragene firadenovec alone and in combination for BCG-unresponsive NMIBC. Neoadjuvant durvalumab plus chemotherapy shows promising pathologic response rates, favorable safety profile in UTUC. Four experts weigh in on their survey-based study of sequencing after 1L EV/pembro in the evolving landscape of la/mUC. Drs. Ghatalia and Nizam break down in detail the RETAIN-2 study, a phase 2 trial of risk enabled therapy for MIBC. EV+P continues to show superior efficacy and durable responses in previously untreated locally advanced or metastatic UC. Dr. Galsky highlights the latest findings on the impact of pCR on long-term outcomes in the NIAGARA trial. Dr. Galsky provides comment on the additional efficacy outcomes in patients with MIBC from the CheckMate 274 study. Dr. Daneshmand provides overviews and updates from three clinical trials involving cretostimogene for high-risk NMIBC. The interim analysis of the RETAIN-2 trial demonstrated a 46% pT0 rate among those undergoing cystectomy.