Dr. Daneshmand discusses the impressive complete response rate and durability of TAR-200 monotherapy for NMIBC. In the PENELOPE study, TAR-200 showed greater tissue penetration of gemcitabine compared to standard intravesical therapy. The panelists share their insights on risk assessment, and customized treatment strategies for high-risk NMIBC. The panelists discuss the evolving landscape of bladder cancer treatments, focusing on balancing bladder-sparing therapies. The panelists debate the potential of combining intravesical immunotherapy with immune checkpoint inhibitors. The panelists share their perspectives on SunRISe-1 and the evolving role of TAR-200 in treating BCG-unresponsive UC. The second segment of this roundtable focuses on the evolving landscape of treatments for BCG-unresponsive bladder cancer. Part one of this roundtable highlights current practices, emerging therapies, and the future landscape of NMIBC care. Dr. Christopher Cutie shares his thoughts on the potential of TAR-200 to redefine care for BCG-unresponsive, HR NMIBC. Dr. Christopher Cutie describes the innovative TAR-200 system and its role in providing sustained intravesical drug delivery. Results of the phase III BOND-003 trial show groundbreaking results of cretostimogene grenadenorepvec for NMIBC. TAR-200 monotherapy is well tolerated and shows promising efficacy in treating HR NMIBC, according to data from SunRISe-1. Durvalumab was granted FDA Priority Review for MIBC, after showing significant survival benefits in the NIAGARA trial. TARA-002 shows promising efficacy, safety in the ADVANCED-2 trial for NMIBC, with high response rates across BCG exposures. Robotic cystectomy after neoadjuvant immunotherapy shows higher severe complication rates than surgery alone. In the final segment of the roundtable, the panel debates the real-world integration of new therapies into everyday practice. In part five of this NMIBC roundtable, the panelists discuss integrating new therapies such as TAR-200 into clinical practice Part four of this roundtable series examines the SunRISe-1 trial results for high-risk NMIBC. The panelists discuss advancements in NMIBC treatment in part three of this roundtable, including pembrolizumab and TAR-200. Part two of this roundtable explores intravesical and systemic therapies, and the importance of accurate risk stratification.