The panel explores the distinct roles of alpha and beta emitters in radiopharmaceutical therapy for prostate cancer care. The expert panel discusses emerging biomarkers and treatment combinations for CRPC and mHSPC. The evolving role of RLT and radium-223 in managing metastatic mHSPC and CRPC is discussed. The panel examines the impact of the latest data from ARANOTE and PEACE-3 in part three of this roundtable. The panelists discuss key considerations for patient selection in doublet and triplet therapies for mHSPC and CRPC. In part one of this roundtable, the panel discusses advances in imaging and tailored treatment strategies for prostate cancer In part four of this roundtable series, the panelists discuss CRPC and the typical patterns of presentation. Part three of this roundtable delves into genomic biomarkers and the use of doublet and triplet therapies for mHSPC. Part two of the roundtable series explores ADT and novel hormonal therapies for patients with prostate cancer. Part one of a roundtable series on prostate cancer, focusing on defining mHSPC and mCRPC. Dr. Greenstein shares insights on the overall survival benefit of apalutamide over enzalutamide in a recent real-world study. Part five of this roundtable series covers data and insights from the ARANOTE and PEACE 3 trials. Part four of a PCa roundtable series focuses on the effectiveness of ADT with triplet therapy. Part three of this prostate cancer roundtable covers prognostic factors such as Gleason scores and genomic assays. Part two of this roundtable features a discussion on the role of bone scans compared to the newer PSMA PET scans. In the fourth part of our series, the panelists discuss PROs and potential patient comorbidities. In the third part of this series, disparities and the optimization of care is discussed, along with the use of ADT and ARPIs. At ESMO 2024, experts discuss androgen-deprivation therapy in HSPC as well as the ARANOTE trial. Dr. Armstrong reviews a handful of GU studies presented, including NIAGRA and STAMPEDE. Drs. Tawagi and Wallis review the PEACE-III, STAMPEDE, UpFrontPSMA, and SPLASH studies trials at the ESMO Congress 2024.