Previous studies have shown that tumor-informed circulating tumor DNA (ctDNA) can improve clinical outcomes as an effective biomarker for treatment response monitoring (TRM) across various tumor types. A recent retrospective analysis has longitudinally examined ctDNA status and dynamics throughout surveillance and during TRM in patients with metastatic clear cell renal cell carcinoma (ccRCC) and non-clear cell RCC (nccRCC) treated with immunotherapy or targeted therapies. ...