Localized Renal Cell Carcinoma

Partial, Radical Nephrectomy After ICIs for Complex Locally Advanced RCC
Surgery for locally advanced renal cell carcinoma (RCC) may be safe for patients after neoadjuvant durvalumab +/- tremelimumab, according to the results of a phase 1b study presented at the 24th Annual Meeting of the Society of Urologic Oncology. Prior research has demonstrated the effectiveness of immune checkpoint inhibitors (ICIs) for metastatic RCC, and new studies are beginning to investigate the utility of ICIs in the neoadjuvant and adjuvant settings. Currently, the changes resulting from immune checkpoint inhibition on the renal and perinephric tissue remain unclear, and the ...
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