Nivolumab is commonly used for the treatment of renal cell carcinoma (RCC) due to the efficacy seen in past trials, including CheckMate 025 and CheckMate 214. Standard-of-care treatment for patients with intermediate- to high-risk RCC consists of partial or radical nephrectomy and surveillance, but a recent study by Mohamad E. Allaf, MD, and colleagues compared the use of nivolumab before nephrectomy followed by adjuvant nivolumab with surgery only in patients with high-risk RCC to determine which ...