In the final segment of this roundtable, the panelists discuss the search for novel targets and strategies to improve renal cell carcinoma (RCC) treatment, particularly in the refractory setting. The conversation highlights promising advancements such as LAG-3, updated interleukins, CAR-T therapies, and bispecific antibodies, as well as the challenges of balancing toxicity and efficacy in these approaches. The panelists also discuss the role of novel therapies in both the frontline and refractory settings, emphasizing the need for innovative, curative strategies. Insights from the TiNivo-2 study are explored, particularly its implications for VEGF inhibitor strategies and its impact ...