Renal Cell Carcinoma

Genomic Study of Fumarate Hydratase-Deficient RCC
At the 2024 American Society of Clinical Oncology Annual Meeting, Xingming Zhang, MD, and colleagues presented results from their recent study, which investigated the molecular subtypes of fumarate hydratase-deficient renal cell carcinoma (FH-deficient RCC). Researchers evaluated the tissue samples of 126 treatment-naïve patients collected from a multicenter database, including conducting whole-exome, RNA, and DNA-methylation sequencing. FH/2SC immunohistochemical staining and FH alterations analysis were used to confirm cases of FH-deficient RCC. ...
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