Data show that of patients with prostate cancer, Black men face higher incidence and mortality rates than White men. For the treatment of localized prostate cancer, guidelines typically recommend the addition of ADT to RT in certain patients. Drs. Stifelman and Ambinder discuss the novel approaches and adoption challenges of single-port and Da Vinci 5 systems. Dr. Shore discusses treatment-related adverse events associated with apalutamide and ADT. Dr. Shore discusses the effects of apalutamide plus ADT in patients with prostate cancer. Drs. Joshua and Wallis contextualize the Metformin Active Surveillance Trial for management of low-risk prostate cancer. New research provides evidence of 18F-rhPSMA-7 leading to more favorable disease outcomes for patients with BCR after RP. The MAST trial evaluated metformin’s effects on reducing progression of low-risk prostate cancer during active ... Researchers attempted to confirm whether treatment suspension for EMBARK patients may lead to improvements in HRQOL. Prostate cancer is the 2nd most diagnosed cancer among men worldwide, but the disease lacks established re-treatment options. The trial evaluated the data of treatment-naïve patients who underwent RP and received apalutamide as well as ADT. Development of a novel risk score for early intensification approaches to RT or salvage RT for pN1 receiving RP. Investigators found that the NCHT cohort demonstrated increased 3-year bPFS benefits compared to the NHT cohort. Dr. Spratt ponders the evolving integration of RT with systemic treatments, challenges in counseling patients, and more. Prostate-specific antigen density was the only clinical variable significantly associated with csPCa other than PI-RADS 5. Dr. Canfield shares real-world active surveillance among men with localized PC tested with the genomic prostate score assay. The 17-gene GPS assay can help physicians with clinical management plans for patients with localized PC. cN1 patients with PCa who undergo initial treatment with RT have worse PCSM outcomes than those treated with RP. Dr. Spratt reviews the safety and efficacy of relugolix plus RT in patients with localized or advanced prostate cancer. Dr. James Sylora shares his career, patient care, and vision for surgical and therapy advancements in community urology.