The combination of ADT and radiotherapy can provide quick benefits in patients with intermediate- or high-risk localized PCa. Dr. Yerram elucidates the evolving landscape of focal therapy for prostate cancer, emphasizing its ease of adoption. Dr. Yerram describes his post-HIFU surveillance protocol: regular PSA checks, MRI, and biopsies at defined intervals. Dr. Yerram explains the use of HIFU and cryotherapy as primary focal therapy modalities, emphasizing a few treatment options. Dr. Yerram explains how advances in focal therapy technologies over the past decade have driven increased use and acceptance. Dr. Sonpavde showcases a phase I/Ib clincial trial on the safety of a neoadjuvant darolutamide and relugolix combination. Dr. Keizman showcases his research on using Decipher for early prostate cancer for USA versus non-USA populations. Dr. Ghoreifi characterizes the activity of inflammasome genes and their association with oncological outcomes in PC. Patients with very high-risk disease saw greater benefit from long-term ADT use compared to those with high-risk disease. Dr. Sanchez-Salas comments on whether PSMA PET is useful for determining optimal candidates for focal therapy. Dr. Sanchez-Salas details strategies for selecting between focal therapy versus active surveillance or definitive treatments. Dr. Kaouk presented on the benefits of surgery for managing biochemically recurrent prostate cancer post-radiation. Dr. Thompson, Jr. highlights his recently published large dataset of long-term complications of prostate cancer treatment. Drs. Saji and Lebastchi explore focal therapy, covering its historical evolution, techniques, and energy modalities. Dr. Ghazi is recognized as a pioneer in patient-specific surgical simulation, using state-of-the-art techniques in surgery. Drs. Saji and Lebastchi provide an in-depth overview of focal therapy for prostate cancer, including HIFU and IRE therapies. GETUG 14 recruited patients with both intermediate- and high-risk PCa, randomizing them to receive RT or stADT plus RT. Dr. Greenstein shares insights on the overall survival benefit of apalutamide over enzalutamide in a recent real-world study. Patients were guided through a VR experience to view their specific anatomy in a 3-dimensional space. Data show that of patients with prostate cancer, Black men face higher incidence and mortality rates than White men.