Advanced Urothelial Carcinoma

EV-302: EV Plus Pembrolizumab Improves OS, PFS in Untreated, Advanced Urothelial Carcinoma
The phase 3 KEYNOTE-A39/EV-302 study has met its dual primary end points of overall survival (OS) and progression-free survival (PFS) in previously untreated, locally advanced or metastatic urothelial carcinoma (la/mUC), according to the latest topline results. The trial assessed the combination of enfortumab vedotin-ejfv (EV) plus pembrolizumab versus chemotherapy (gemcitabine plus cisplatin or carboplatin). Investigators enrolled patients who may or may not be eligible for treatment with cisplatin-based chemotherapy, regardless of PD-L1 status. ...
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