Muscle Invasive Urothelial Carcinoma

Primary Analysis of Gemcitabine, Cisplatin Plus Neoadjuvant Durvalumab in MIBC
The single-arm, phase 2 SAKK 06/17 trial analyzed the addition of neoadjuvant durvalumab to gemcitabine/cisplatin chemotherapy in patients with muscle-invasive bladder cancer (MIBC) followed by radical surgery and adjuvant checkpoint inhibition with durvalumab. The study analyzed 54 cisplatin-fit patients with stage cT2-T4a cN0-1 operable MIBC from 12 treatment sites. Patients were administered 4 cycles of neoadjuvant gemcitabine/cisplatin combined with 4 cycles of durvalumab (starting at the second gemcitabine/cisplatin cycle) followed by radical surgery. Adjuvant durvalumab was administered for 10 ...
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