Investigators assessed the impact of androgen receptor (AR) gene alterations in patients with metastatic castration-resistant prostate cancer (mCRPC) receiving first-line treatment with AR-targeted agents (ARATs). Lead author of the study, Nishita Tripathi, reported that patients with mCRPC who had AR alterations in circulating tumor DNA (ctDNA) had worse outcomes compared with patients with wild-type AR status. The data were presented at the ESMO Congress 2022. ...
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