David Morris, MD, FACS; John Phillips, MD; Jeremy McDuffie, MD; Katy Beckermann, MD, PhD; and Alan Tan, MD, explore the distinct roles of alpha and beta emitters in radiopharmaceutical therapy, the promise of triplet therapy, and the integration of precision medicine in the final segment of this roundtable series. They discuss the operational challenges and clinical considerations of radioligand therapies like lutetium-177 PSMA and radium, their impact on patient outcomes, and the potential to move these therapies earlier in the treatment paradigm. ...