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Zachary Bessette
Zachary Bessette
Articles by Zachary Bessette
FDA Approves IL-15 Receptor Agonist for BCG-Unresponsive NMIBC
Zachary Bessette
Non-Muscle Invasive Urothelial Carcinoma
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April 23, 2024
The FDA approved Anktiva for patients with BCG-unresponsive NMIBC with CIS with or without papillary tumors.
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Nadofaragene Firadenovec Clinical Trial Program Expands in NMIBC
Zachary Bessette
Non-Muscle Invasive Urothelial Carcinoma
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April 16, 2024
Ferring Pharmaceuticals has expanded their Adstiladrin clinical trial program to include 3 new studies in NMIBC.
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FDA Accepts IND for UGN-103 in Low-Grade Intermediate-Risk NMIBC
Zachary Bessette
Non-Muscle Invasive Urothelial Carcinoma
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April 15, 2024
The FDA has accepted the Investigational New Drug Application for UGN-103 for low-grade intermediate-risk NMIBC.
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Predicting Renal Function Improvement After Partial Nephrectomy
Zachary Bessette
Localized Renal Cell Carcinoma
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April 8, 2024
Dr. Afari and colleagues sought to better understand factors leading to renal function improvement after partial nephrectomy.
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Rescue BCG for Patients With BCG-Unresponsive Bladder Cancer
Zachary Bessette
Non-Muscle Invasive Urothelial Carcinoma
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April 8, 2024
Some patients who meet the FDA criteria for “BCG-unresponsive” bladder cancer may benefit from additional BCG therapy.
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Real-world Utilization of Genomic Prostate Score Assay Among Men With Localized Disease
Zachary Bessette
Localized
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April 9, 2024
The 17-gene GPS assay can help physicians with clinical management plans for patients with localized PC.
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Long-term Outcomes of Nephron-Sparing Surgery Versus RNU for Organ-Localized UTUC
Zachary Bessette
Upper Tract Urothelial Carcinoma
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April 8, 2024
Patients who undergo RNU have comparative or better long-term outcomes than patients undergoing NSS for organ-localized UTUC.
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FDA Approves Nivolumab With Cisplatin-Gemcitabine for Unresectable or Metastatic UC
Zachary Bessette
Advanced Urothelial Carcinoma
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March 7, 2024
Approval came as a result of the CheckMate 901 study, a randomized trial that enrolled 608 patients with metastatic UC.
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Updated COBRA Results Show SAR-bisPSMA Detects Smaller Lesions
Zachary Bessette
Prostate Cancer Diagnostics
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March 6, 2024
Clarity released updated data on COBRA, confirming that 64Cu-SAR-bisPSMA leads to higher detection of lesions in BCR.
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Prognostic Role of pT3a Staging Subclassifications in RCC by Histologic Subtype
Zachary Bessette
nccRCC
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March 11, 2024
A new study on the prognostic value of perinephric fat, renal sinus fat, and renal vein invasion in patients with pT3a RCC.
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SAR-bisPSMA Is Safe, Effective in Detecting Tumors in Patients With Prostate Cancer
Zachary Bessette
Prostate Cancer Diagnostics
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February 15, 2024
Initial data from the COBRA trial confirm that 64Cu-SAR-bisPSMA is safe and “highly” effective in detecting BCR PC.
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KEYNOTE-564: OS Results From Adjuvant Pembrolizumab for Clear Cell RCC
Zachary Bessette
ASCO GU Symposium 2024
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January 27, 2024
After 57 months of follow-up, adjuvant pembro demonstrates improvement in OS in patients with ccRCC at risk of recurrence.
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Subgroup Analyses Offer New Understandings of EV, Pembrolizumab Benefit in la/mUC
Zachary Bessette
ASCO GU Symposium 2024
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February 5, 2024
Improved outcomes in patients with previously untreated la/mUC after EV/pembro, even in poor prognosis patient subgroups.
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AMBASSADOR: Adjuvant Pembrolizumab in Muscle-Invasive, Locally Advanced UC
Zachary Bessette
ASCO GU Symposium 2024
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February 1, 2024
Adjuvant pembrolizumab demonstrates improvement in DFS for patients with high-risk MIUC after radical surgery.
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Tivozanib Safety, Efficacy in Heavily Pretreated Patients With Advanced Clear Cell RCC
Zachary Bessette
Advanced Renal Cell Carcinoma
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April 1, 2024
A retrospective study of patients with accRCC offers understandings of the role of tivozanib in the current RCC landscape.
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Urinary MRD Detection Predicts Recurrence in BCG-Unresponsive NMIBC, Quantifies Response to Nadofaragene Firadenovec
Zachary Bessette
ASCO GU Symposium 2024
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March 11, 2024
uMRD enables quantitative assessment of molecular response to nadofaragene firadenovec for BCG-unresponsive NMIBC.
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Predictive Value of Dynamic Changes in ctDNA, Baseline Biomarkers for MIBC
Zachary Bessette
ASCO GU Symposium 2024
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March 11, 2024
Researchers performed an exploratory biomarker analysis using different definitions of ctDNA response in the ABACUS trial.
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JAVELIN Bladder 100: Long-term Patient-Reported Outcomes
Zachary Bessette
ASCO GU Symposium 2024
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January 25, 2024
Prolonged avelumab first-line maintenance treatment is associated with stable PROs for those with aUC.
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Erdafitinib, EV Combination Shows Antitumor Activity in mUC With FGFR2/3 Alterations
Zachary Bessette
ASCO GU Symposium 2024
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February 1, 2024
An early-stage trial highlights the antitumor activity from erdafitinib plus EV for mUC with FGFR2/3 genetic alterations.
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CONTACT-2 Shows Benefit of Cabozantinib Combination for mCRPC
Zachary Bessette
ASCO GU Symposium 2024
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January 24, 2024
Cabozantinib plus atezolizumab improves rPFS versus second NHT in patients who had progressed on a prior NHT and have mCRPC.
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