Dr. Hong reviews relevant key findings from clinical trials for oligometastatic disease. Dr. Hong reviews the criteria used to determine which patients may benefit from MDT. Dr. Chu highlights how PSMA PET is transforming perioperative prostate cancer care, including improving surgical precision. Dr. Koshkin highlights emerging data on Nectin-4–targeted imaging and radiopharmaceuticals in urothelial cancer. Dr. Koshkin shares an overview of FAP-targeted theranostics, including UCSF-led studies showing FAP PET imaging’s ability. Dr. Tagawa compares the use of PSMA-targeted antibodies to other treatment approaches such as radioligand therapy. Dr. Kishan reviews current evidence supporting the use of PSMA RLT in patients with oligometastatic disease. Dr. Antonarakis discusses the differences between PARP1 mRNA expression and other biomarkers used for risk stratification. Dr. Morris discusses trials and rationale behind using PSMA therapy earlier in prostate cancer treatment. Dr. Hope evaluates PSMA PET vs SPECT imaging for tracking therapy response in prostate cancer. Dr. Fendler reviews a multi-center study that used prognostic nomograms to risk-stratify patients based on OS. Dr. Hofman outlines promising PSMA combination therapies and emerging trials aiming to improve prostate cancer outcomes. Dr. Calais provides an overview of this year's PSMA and Beyond conference agenda. Noah Hahn, MD, gives an overview of durvalumab with intravesical gemcitabine and docetaxel for BCG-unresponsive NMIBC. Dr. Daniel Joyce gives an overview of his study that examined the use of necrosis as a prognostic indicator for mRCC. Drs. Karine Tawagi and Samantha Armstrong expand on the prostate cancer discussions of note, including TALAPRO-2. Drs. Tawagi and Armstrong provide detail and discussion on the bladder cancer research from the 2025 ASCO GU meeting. Drs. Tawagi and Armstrong recap the hottest topics in kidney cancer research from the 2025 ASCO GU Cancers Symposium. Dr. Sonpavde provides an update on the latest analysis from the phase 3 global study of EV in combination with pembro. Dr. Sonpavde showcases a phase I/Ib clincial trial on the safety of a neoadjuvant darolutamide and relugolix combination.