Dr. Li provides commentary on the rationale, design, and impact of the MoonRISe-1 study for intermediate-risk NMIBC. Dr. Soon-Shiong provides an overview of the groundbreaking data related to nogapendekin alfa inbakicept for NMIBC. Dr. Li highlights the significance of adverse pathologic features at radical prostatectomy for AS-eligible patients. Continuing his discussion at the AUA 2024 Annual Meeting, Dr. Narayan highlights the latest news on nadofaragene firadenovec. Dr. Narayan breaks down the 5-year follow-up data on nadofaragene firadenovec for patients with BCG-unresponsive NMIBC. Development of a novel risk score for early intensification approaches to RT or salvage RT for pN1 receiving RP. Drs. Joyce and Psutka consider patient counseling for adjuvant RCC therapy, and biomarkers and imaging before treatment. Drs. Ambinder and Sonpavde provide an update for CheckMate 901, characterizing treatment benefit in responders. Drs. Murray and Broenimann highlight and evaluation of urinary genomic profiling for detection and molecular staging of UTUC. A study to determine the potential utility of ADCs targeting TROP-2 in both localized PSCC and distant metastases. Approximately 82,000 new cases of RCC are diagnosed each year in the US, but effective early detection methods are lacking. Drs. Murray and Lotan review the development and validation of AI biomarkers to predict outcomes in BCG-treated NMIBC. Drs. Murray and Lotan highlight a recent multicenter study featuring longitudinal follow-up of UGN-101 for UTUC. Dr. Spiess highlights prevalence of TERT expression and an increase in TROP-2 mRNA expression levels in PSCC patients. Dr. Nyame shared highlights from his presentation on PC screening in high-risk groups as part of an AUA plenary session. Researchers found increased OS and PFS benefits when patients received nivolumab plus gemcitabine. New findings from the Nure-Combo trial examined the use of ABX with nivolumab followed by RC and adjuvant nivolumab. Dr. Lerner shares updates from the ENLIGHTED trial and analyses pertaining to NAC for UTUC from the ROBUUST registry. Drs. Joyce and Khanna examine the utility of a deep learning algorithm for automated renal volume calculation. For patients with clinical node-positive UTUC, NAC may lead to improved outcomes compared with adjuvant chemotherapy.