Dr. Nima Sharifi joins The Uromigos to discuss mechanisms of resistance to hormone therapy in prostate cancer. Drs. Cristina Suárez, Elena Castro, and María Teresa Bourlon discuss recent ESMO guideline changes on GU cancers. Drs. Cristina Suárez, Elena Castro, and María Teresa Bourlon host the first Spanish-language ASCO episode for The Uromigos. Drs. Axel Bex, Christian Blank, Laura Mertens and Micheil Van der Heijden get a chance to win The Uromigos Cup. Drs. Viktor Grünwald, Boris Hadaschik and Gunhild Von Amsberg answer trivia for the Uromigos Cup qualifying round. Drs. Nobuaki Matsubara, Hiroshi Kitamura and Yuji Miura answer trivia questions set by Tom and Brian for the Uromigos Cup. Drs. Danny Heng, Christian Kollmannsberger and Kala Sridhar attempt to take on Team LA to win the Uromigos Cup. Silke Gillessen joins Brian and Tom to give a preview of this year's ASCO annual meeting. Dr. Nick James joins the podcast to discuss the recent Lancet Commission paper on prostate cancer. Dr. Silke Gillessen gives a summary of APCCC 2024, including surgery versus RT, genetic and somatic testing, and more. Chris Sweeney is joined by fellow experts to discuss mHSPC side effects such as bone weakness, hot flashes, and gynecomastia. Professor Thomas Suter and Dr. Chuck Ryan discuss cardiovascular risks associated with hormone therapy in prostate cancer. Drs. Thomas Zilli and Pierre Blanchard debate the use of radiation therapy in prostate cancer and oligometastatic disease. Brian and Tom speak with Drs. Piet Ost and Jason Efstathiou on the data for and against radiation therapy in prostate cancer. Daniel Goldstein returns to the podcast to discuss dosing changes in drugs such as nivolumab and pembrolizumab. FDA Deputy Oncology Director Dan Suzman describes approaches to oncology trials in the GU setting. Dr. Tanya Dorff discusses her work on a phase 1 study investigating acapatamab for advanced prostate cancer. Michael Lattanzi, MD, joins the podcast to discuss treatment plans and research in the community oncology setting. Vania Wisdom, Senior Executive Editor at The Lancet, discusses cancer treatment and research in developing countries. Dr. Dana Rathkopf describes the phase 1 data for the androgen receptor ligand-directed degrader in prostate cancer.