Dr. John Heymach discusses a novel PD1/VEGF bispecific agent in lung cancer and its potential applications in GU oncology. Dr. Chuck Ryan of Memorial Sloan Kettering Cancer Center joins us to discuss Dr. Felix Feng's keynote address. Silke Gillessen joins the podcast to discuss the top areas of consensus and controversy from APCCC 2025. Dr. Tyler Seibert provides updates from the 2025 APCC Diagnostics conference. Dr. Silke Gillessen joins the show to discuss some of the top highlights from this year's ASCO GU conference. Returning guest Dr. Toni Choueiri discusses the updated data from different cohorts of this novel HIF inhibitor. Dr. Vincent Xu of Dana-Farber Cancer Institute discusses this emerging RCC biomarker and data from the Checkmate 214 trial. Returning guest Dr. Laurence Albiges discusses novel combos in refractory RCC and gives an update on COSMIC-313. Dr. Gopa Iyer of Memorial Sloan Kettering Cancer Center joins the show to discuss his initial results. Dr. Matt Galsky joins the show to discuss pathological complete response rates from the NIAGARA trial. Dr. Xinan Sheng joins the podcast to discuss the update of this trial and impressive pCR rates. Dr. Tanya Dorff discussed results of the STOPCAP trial from ASCO GU 2025, along with new data from TALAPRO-2. Dr. Neeraj Agarwal joins Tom and Brian for an in-depth look at important data from TALAPRO-2. Silke Gillessen joins Brian and Tom to discuss what to look forward to in prostate, bladder and RCC at ASCO GU 2025. David Braun, MD, PhD joins the show to discuss his Nature paper on a personalized RCC vaccine. Romain Banchereau, PhD, joins the show to discuss and debate this Cancer Cell paper on molecular subtypes in UC. Professor Shankar Siva joins the show to discuss the emerging role of stereotactic body radiotherapy in RCC tumors. Dr. Dorff reviews expectations for GU oncology updates in 2025. Dr. Silke Gillessen is joined by special guests to discuss the top highlights from 2024 in the prostate cancer field. Dr. Matt Galsky joins Brian and Tom to discuss the most impactful data in bladder cancer from 2024.