Many patients diagnosed with localized prostate cancer will undergo primary therapy with radical prostatectomy. An estimated 25% to 40% of such patients will eventually experience biochemical recurrence (BCR) by 10 years after primary therapy.1,2 Postprostatectomy patients with BCR may be offered salvage radiation therapy if they have a rising detectable prostate-specific antigen (PSA) level and no radiographic evidence of nodal or metastatic disease. At the American Society for Radiation Oncology (ASTRO) 2022 meeting, several authors presented abstracts on the topic of postprostatectomy radiation that are worth reviewing. ...