GU Oncology Now Editors

GU Oncology Now

A retrospective study from Nishita Tripathi, MD, and colleagues, presented in Poster Session B, Urothelial Carcinoma, at the 2022 American Society of Clinical Oncology (ASCO) Genitourinary Cancers Symposium, compared genomic profiles of locally advanced or metastatic urothelial carcinomas with squamous differentiation (UCS) to standard urothelial carcinoma (UC). They noted that alterations of the KMT2D gene were significantly more frequent in the UCS cohort, and supplied that, &ldquo;it is interesting to note that both KMT2D and CUL4A (higher frequency in UCS) are involved in epigenetic regulation.&rdquo;The trial included patients with advanced UCS and UC undergoing tumor-based genomic profiling. Genes with alterations in less than 5% of patients, patients with secondary variants of UC, and patients with variants of unknown significance were all excluded from the analysis.A total of 87 patients were included in the study, 31 of which had UCS and 56 had UC. KMT2D genes with alterations were significantly enriched in the UCS group versus the UC group (15/31 vs, 0/56; false discovery rate [FDR] &lt;0.001, p &lt;0.001). Additionally, CUL4A alterations were numerically higher for UCS compared to UC (4/31 vs. 1/56, FDR= 0.444; p = 0.03). Interestingly, the investigators observed that the &ldquo;frequency of genomic aberrations per patient were not significantly different in the groups.&rdquo;While the authors acknowledged that their &ldquo;hypothesis-generating data&rdquo; was limited by small sample size, selection, and confounding biases, they felt it warranted external validation. Ultimately, they suggested that &ldquo;identification of underlying molecular targets and biomarkers can guide further drug development in this population.&rdquo;

Tumor Landscapes in Urothelial Carcinoma With or Without Squamous Differentiation

American Society of Clinical Oncology Genitourinary Cancers Symposium 2022

ASCO GU Symposium 2022

Tumor Landscapes in UC With/Without Squamous Differentiation

About Us

Contributors and Partners

Editorial Policy

Advertising

eNewsletters

Calendar

Contact Us

Contribute

MashupMD

Cancer Nursing Today

Urban Health Today

Blood Cancers Today

DocWire News

Knowledge Hubs

Conference Coverage

Roundtables

The Uromigos

Uromigos Live 2024

AUC3

Localized

mHSPC/mCSPC

CRPC

Diagnostics

Prostate Cancer

Localized Renal Cell Carcinoma

Advanced Renal Cell Carcinoma

nccRCC

Renal Cell Carcinoma

Non-Muscle Invasive Urothelial Carcinoma

Muscle Invasive Urothelial Carcinoma

Advanced Urothelial Carcinoma

Upper Tract Urothelial Carcinoma

Urothelial Carcinoma

Testicular, Penile, and Rare Cancers

Video Insights

Advancements in Oncology

The Oncology Brothers

Expert Interviews

Journal

Subscribe