Survivors of testicular germ-cell tumors (TGCT) were at increased risk for developing skin cancer and melanoma, according to a meta-analysis published in the Journal of the European Academy of Dermatology and Venereology.
Previous research has suggested an increased risk for skin cancer among TGCT survivors, and many survivors are referred for life-long monitoring with a dermatologist.
In this review and meta-analysis, researchers looked at literature examining the association between TGCT and skin cancer risk. They included any studies that had more than 10 TGCT survivors reporting on skin cancer incidence. Nineteen studies that included 147,935 survivors were included.
Compared with the general population, the pooled standardized incidence rate (SIR) for skin cancer among TGCT survivors was 1.93 (95% CI, 1.62-2.29; P<.0001); for melanoma the SIR was 1.81 (95% CI, 1.57-2.08; P<.0001). For skin cancer the researchers said the included studies had substantial heterogenicity of SIR variation; for melanoma there was moderate heterogenicity.
An evaluation of factors influencing skin cancer risk showed that subtype, participants’ age at beginning of follow-up, years of follow-up and follow-up duration, surgical treatment, and chemotherapy did not show a significant difference in melanoma SIR.
“Regarding screening, patient education about the importance of UV protection and self-skin examination should be the cornerstone of management,” the researchers wrote. “In addition, periodic skin cancer surveillance should be considered in this population.”