A study assessed the link between benign prostatic hyperplasia (BPH) and prostate cancer (PCa) by testing for phenotypic and genetic correlation. The results were published in European Urology Open Science.
In this study, the investigators assessed the association between BPH and PCa by testing phenotypic correlation using chi-square, genetic correlation (r g) based on genome-wide single nucleotide polymorphisms (SNPs) among 214,717 White men in the UK.
According to the results, diagnoses of BPH and PCa were significantly correlated. Moreover, the study found appreciable cross-disease genetic associations for established risk-associated SNPs. The researchers observed that among the 250 established genome-wide association study-significant SNPs of PCa or BPH, 49 were significantly associated with the risk of the other disease at p < 0.05, which was significantly more than expected. “BPH and PCa share common inherited genetics, which suggests that the phenotypic association of these two diseases in observational studies is not entirely caused by the detection bias,” the researchers concluded.