Emily Menendez

GU Oncology Now

Renal cell carcinomas (RCCs) are often localized and are commonly managed through active surveillance, surgery, or minimally invasive techniques. <a href="https://www.sciencedirect.com/science/article/abs/pii/S0302283823026258" target="_blank" rel="noopener">Hannan et al</a> conducted a study to determine if stereotactic ablative radiation (SAbR) is effective for the management of primary RCCs. SAbR could potentially serve as a new noninvasive alternative treatment, but data on the procedure are limited.A total of 16 patients were enrolled in the study. Each patient had biopsy-confirmed, radiographically enlarging, primary RCC (&le;5 cm). The study&rsquo;s primary end point was local control (LC), defined as a reduction in tumor growth rate compared with a benchmark of 4 mm/year on active surveillance, and pathologic evidence of tumor response at 1 year.Secondary end points included LC as measured by the Response Evaluation Criteria in Solid Tumors (RECIST), safety, and preservation of kidney function. Further exploratory tumor cell-enriched spatial protein and gene expression analyses were conducted on pre- and posttreatment biopsy samples.At 1 year, radiographic LC was observed in 15 (94%) patients and accompanied by pathologic evidence of tumor response such as hyalinization, necrosis, and reduced tumor cellularity in all patients. According to RECIST, 100% of the treatment sites also remained progression-free at 1 year.The median pretreatment growth rate was 0.8 cm per year (interquartile range [IQR], 0.3-1.4), while the median posttreatment growth rate was 0 cm per year (IQR, &ndash;0.4 to 0.1; P&lt;.002). Tumor cell viability decreased from 4.6% to 0.7% at 1 year (P=.004). With a median follow-up of 36 months for censored patients, the disease control rate was 94%.SAbR was well-tolerated, with no grade &ge;2 (acute or late) toxicities. The average glomerular filtration rate declined from a baseline of 65.6 ml/min to 55.4 ml/min at 1 year (P=.003). Spatial protein and gene expression analyses were consistent with the induction of cellular senescence by radiation.The trial found SAbR to be a safe and effective noninvasive treatment option for patients with primary RCC.

Stereotactic Ablative Radiotherapy Is Safe and Effective for Primary Renal Cancer

Localized Renal Cell Carcinoma

A recent study determined if stereotactic ablative radiation can be effective for the management of primary RCCs, as data on the procedure are limited.

Stereotactic Ablative Radiotherapy Safe, Effective for RCC

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