Polygenic Hazard Score Predicts Prostate Cancer Risk in Veterans

By Robert Dillard - Last Updated: November 18, 2022

A polygenic hazard score based on 290 genetic variants (PHS290) is able to stratify US veterans of diverse ancestry for lifetime risk of prostate cancer, including metastatic and advanced cancer, including to a study published in the Journal of the National Cancer Institute.

In this retrospective analysis, researchers analyzed 590,750 male participants from the Million Veteran Program (MVP), a national, population-based cohort study of US military veterans conducted 2011-2021. They researchers noted that they used cox proportional hazards analyses to assess the correlation of genetic and other risk factors (including self-reported race and ethnicity and family history) with age at death from prostate cancer, age at diagnosis of metastatic (nodal or distant) prostate cancer, and age at diagnosis of any prostate cancer.

According to the results, PHS290 was linked with fatal prostate cancer in the full cohort and for each racial and ethnic group. The researchers observed that PHS290 was a strong independent predictor of any, metastatic, and fatal prostate cancer.

PHS290 stratified US veterans of diverse ancestry for lifetime risk of prostate cancer, including metastatic and fatal cancer. Predicting genetic risk of lethal prostate cancer with PHS290 might inform individualized decisions about prostate cancer screening,” the researchers concluded.

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